A recent study suggests that people who come off blockbuster GLP-1 drugs like semaglutide or tirzepatide may regain reduced body mass far faster than those who end conventional diet and exercise regimens.
Research printed in a leading medical journal points out that while overweight people can lose about a fifth of their body weight while on the medication, the mass is regained at an estimated rate of nearly a kilo each month upon discontinuation.
"Users purchasing such treatments must be aware of the potential of rapid rebound weight gain when the treatment is stopped," warns researcher Dr. Susan Jebb.
That rate of regain implies a reversion to starting weight within about a year and a half.
Analyzing Approaches
The analysis, which looked at dozens of trials involving over 9,000 of patients, contrasted the effects of these new drugs with conventional dieting.
Researchers emphasize that individuals who lose weight through lifestyle changes alone typically see a less rapid creep back—around 100 grams monthly—post-intervention.
The Reason for the Fast Regain
Doctors propose the way of the drugs explains the heightened rebound.
The injections mimic a body's own chemical called glucagon-like peptide-1, which helps regulate hunger.
"Long-term administration of the hormone levels far above than the body's typical production could lead to the system to generate a reduced amount of its own natural hormone, and may also reduce sensitivity to its actions," explained Dr. Adam Collins, a nutrition specialist.
"Discontinuation of this medication results in appetite is uncontrolled, making excessive eating much more probable."
An Ongoing Condition?
Health authorities recommend the injections for people with weight-linked medical conditions, alongside recommended lifestyle changes.
Professionals argue that, due to the likelihood of relapse, the treatment might need to be long-term.
This opinion is supported by drug manufacturers, who note that the findings "highlight the chronic character of excess weight," akin to managing conditions like high blood pressure.
Patient Experiences
Users who have discontinued the jabs report a powerful return of cravings.
"It was like a trigger activating and you become ravenous," recalled an individual.
The struggle is exacerbated if individuals have not adopted sustainable dietary or behavioural modifications during therapy.
Growing Adoption
Recent estimates show that millions of people in the UK have used weight-loss jabs in the past year, with desire being substantial.
- Use is greater among women than males.
- The middle-aged demographic shows the highest level of interest.
- Many obtain the medications through private healthcare rather than public health services.
Finally, researchers emphasize that while these medications are powerful tools for weight loss, they are not a permanent fix and maintained weight loss relies on ongoing lifestyle management.
